More About Our Technology
American BioOptics uses a platform of complementary light-scattering screening technologies to identify manifestations of field carcinogenesis — a well-established biological phenomenon that suggests subtle and detectable abnormalities occur throughout an organ when cancer is present nearby.
We can identify field carcinogenesis with outstanding accuracy with our technology, a sophisticated platform of unique, patented light scattering technologies that allow characterization of the nanoscale architecture of the cell, and can be sensitive to particles 10-20 times smaller than seen with conventional light microscope.
Identification of subtle abnormalities inside the colon can help physicians recognize patients at high risk for cancer.
ABO holds an exclusive license to six pending patents on optics technologies. They include:
Low Coherence Enhanced Backscatter (LEBS)
This technology senses nanoscale cellular change in vivo — changes on the size of fundamental cellular building blocks such as DNA and proteins whose alterations are associated with field carcinogenesis — by characterizing the constructive interference of photons traveling time-reversed paths in tissue.
- LEBS is sensitive to changes in intracellular organization that are otherwise undetectable by histology.
- LEBS signals mostly depend on the second-order scattering of weakly localized photons by tissue structures. This contrast mechanism is unique to LEBS and cannot be probed by existing techniques.
- LEBS enables physicians and technicians to identify potential risk for the development of cancer and its progression by sensing changes in histologically normal-appearing tissue at a distance from a cancerous lesion.
Four-dimensional Elastic Light-Scattering Fingerprinting (ELF)
This technology obtains comprehensive data from photons undergoing single light scattering in tissue. ELF-based techniques have been shown to allow precise localization of polyps during colonoscopy through an endoscopically compatible probe. 4-D ELF allows acquisition of light-scattering data in several dimensions. These include wavelength of light, the scattering angle, azimuthal angle of scattering and polarization of scattered light.